Clinical and laboratory parameter analysis in patients with common Variable Immunodeficiency

Introduction: Common Variable Immunodeficiency (CVID) is the most prevalent primary immunodeficiency in adult population. The diagnosis based on low concentration of at least 2 immunoglobulin classes, mostly IgG, with IgA and/or IgM. Beside recurrent infections, patients CVID usually suffer from different respiratory, gastrointestinal, autoimmune and malignant diseases. Leading therapeutic approach to managing regular intravenous (IVIG) subcutaneous (SCIG) replacement therapy. Aim: aim study was analyze clinical laboratory parameters CVID. Material methods: present included 24 who were treated Clinic Allergy Immunology, University Clinical Center Serbia 2012 2022. Demographic data, obtained patients' medical records. concentrations IgM measured by nephelometry. Statistical analysis performed using descriptive methods, Student t test for independent samples Fisher exact test. Results: Respiratory manifestations found 70.8% patients, gastrointestinal 45.8%, 29.2% malignancies 20.8%. presence diseases common within aged between 20 30 years, it statistically significantly higher comparing other age groups (p = 0.014). Serum IgG 7.6 ± 2.7 g/l measured. Statistically observed receiving SCIG (10.2 1.6), compared those IVIG (6.7 2.4) (t -3.3, p 0.003). Premedication required 44.4% IVIG. Conclusion: complication are chronic lung Autoimmune frequently diagnosed ages 30. use identified as better form Total serum measuring infections can contribute timely diagnosis.